Founded in 2011 as a partnership of renowned academic, medical and industry leaders, the New York Genome Center (NYGC) focuses on translating genomic research into clinical solutions for serious disease. In the not-too-distant future, scientists anticipate that every patient entering a hospital for the first time will have their genome sequenced, and the data stored in their electronic health records. Reducing the cost further is essential to spark the next wave of genomic discovery and its translation into clinical application for improved human health outcomes. This grant provides support for a revolutionary new instrument that will dramatically decrease the cost of sequencing and increase the scale and scope of research and clinical whole genome sequencing possibilities.