To develop an integrated collaborative HSS Genomics Center that will partner with the New York Genome Center to advance genomics research in autoimmune diseases. This partnership will leverage the complementary expertise of the two institutions in autoimmune diseases and genomics to make breakthrough discoveries that can lead to new treatments. The HSS Genomics Center will initially focus on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), with the potential to extend to other autoimmune and musculoskeletal diseases as the Center and its research programs mature.